Cenforce® 200mg

Description

Description of Cenforce® 200 mg

One of the most popular in Germany and Europe and safe generic Viagra is – Cenforce® 200mg . This is a drug from the Indian manufacturing company Centurion Laboratories. The remedy is prescribed by sex therapists to men for the treatment of vascular and psychological erectile dysfunction. The drug relieves the stronger sex of erection problems. It increases blood flow to the genitals, which guarantees a persistent erection and long sexual intercourse. With the drug, male self-esteem increases, but a source of natural arousal is also necessary.

Cenforce® 200mg (Double Strength) – a drug with a double dosage (improved formula) of the active ingredient Sildenafil. In the standard dosage – 100 mg. Aimed at the treatment and restoration of male power, improvement of sexual functions, endurance, as well as thickening of erection and prolongation of sexual intercourse.

Cenforce® 200mg first established itself on the pharmaceutical market more than ten years ago and now confidently occupies a leading position in its field. This generic drug became one of the first drugs that can almost instantly cause an erect state in all male representatives, regardless of age. Such a discovery was a real shock for the world’s scientists and for ordinary consumers. For several years now, the popularity of Cenforce® 200mg has increased sharply, because the tablets have helped many men who have already lost hope of a normal intimate life.

Indications for the use of Cenforce® 200mg:

• Erectile dysfunction at various stages;
• Age-related sexual impotence;
• Mental problems, shyness.

Cenforce® 200mg-when to use

Cenforce® 200mg must buy those who are involved in the therapy of various types of impotence, rehabilitation of erectile function, increasing the level of libido, restoring full-fledged life in familiar foot. Erectile dysfunction can be caused by psychological and physiological factors. The tablets described above relieve any type of impotence. They can be used by men of any age (from 18 years).

Double the dosage of this medication is recommended:

• men with a body weight of more than 90 kg
• age 40 and older
• with an unstable, sluggish erection and its complete absence
• as a saving (you can divide a whole tablet in half and drink half)

What is the difference between Cenforce® 100mg and Cenforce® 200mg?

• Tablets Cenforce® 200mg, this is an increased dosage of the drug, from the manufacturer’s company.
• In each tablet – twice as much active ingredient.
• Viagra is prescribed to treat sexual impotence in men of different ages.
• Helps to increase the speed of excitation of the reproductive system.
• Improves the elasticity of the erection. Prolongs sexual intercourse.

How does Cenforce® 200 mg work?

Sildenafil is a powerful selective inhibitor of cycloguanosine monophosphate (cGMP) – specific phosphodiesterase type 5 (PDE5). Restores impaired erectile function under conditions of sexual stimulation of increasing blood flow in the vessels of the penis.

Pharmacological effect of Cenforce® 200 mg?

The physiological process underlying penile erection involves the release of nitric oxide (NO) in the corpus cavernosum against the background of sexual stimulation. Nitric oxide activates the enzyme guanylate cyclase, which leads to an increased concentration of cGMP and subsequent relaxation of the smooth muscle cells of the corpus cavernosum, promoting its filling with blood.

Does not have a direct relaxing effect on the isolated cavernous body of a person, but enhances the effect of NO by inhibiting PDE5, which is responsible for the breakdown of cGMP. If you activate the NO/cGMP system against the background of sexual stimulation, inhibition of PDE5 under the influence of Sildenafil leads to an increase in the level of cGMP in the cavernous body.

Sexual stimulation is necessary for the development of the desired pharmacological effect of Sildenafil.

Pharmacokinetics Cenforce® 200 mg

• Sildenafil is rapidly absorbed. Cmax in blood plasma when taken on an empty stomach is reached within 30-120 min (median 60 min). Absolute bioavailability is on average about 41% (25-63%). Pharmacokinetics (AUC and Cmax) of sildenafil in the range of recommended doses (25-100 mg) is linear. Eating reduces the rate of absorption of sildenafil, and the time to reach C max is prolonged on average by 60 minutes, Cmax decreases on average by 29%.
• Vd Sildenafil in equilibrium is on average 105 l. After a single intake of 100 mg of Sildenafil (C) Max is over 440 ng / ml (coefficient of variation (CV) 40%). Since Sildenafil (and its main circulating N-demethylated metabolites) are 96% bound to plasma proteins, the average concentration in the blood plasma of the free fraction of Sildenafil is 18 ng / ml (38 nM). In healthy volunteers, 90 minutes after a single dose of 100 mg of Sildenafil in the semen is determined less than 0.0002% of the dose (on average 188 ng).
• Sildenafil is metabolized mainly in the liver under the influence of microsomal cytochrome P450 isoenzymes: CYP3A4 (main pathway) and CYP2C9 (additional pathway). The main circulating active metabolite is formed as a result of N-demethylation of sildenafil. The selectivity of the metabolite to phosphodiesterase is comparable to that of sildenafil, and its activity against PDE5 in vitro is about 50% of the activity of unchanged sildenafil. The concentration of the metabolite in the blood plasma of healthy volunteers is about 40% of the concentration of sildenafil. N-demethylated metabolite is further metabolized, its T1 / 2 is over 4 h.
• The total clearance of sildenafil is 41 l/h, and the final T1/2 – 3-5 h. Sildenafil is excreted as metabolites, mainly through the intestine (about 80% dose) and, to a lesser extent, the kidneys (about 13% dose).

Functional principle Cenforce® 200mg

Cenforce® contains 200 mg of the active ingredient Sildenafil. By chemical origin, it is salt that is able to influence the physiological processes of the human body . The heartbeat accelerates, blood flow in the pelvic organs increases. The nitric oxide stored in the body is released, which facilitates the relaxation of smooth muscles and the penis swells noticeably.

Male libido increases, sexual desire increases. The male organ remains elastic and firm for a long time. Multiple intimate intimacy with the achievement of multiple orgasms becomes easily accessible, immediately comes a new erection. A young male body without physiological problems can have psychological barriers in contact with the opposite sex.

Cenforce® 200 mg strengthens attraction, gives confidence and subsequently forms a reliable erection for intimacy. After eliminating the psychological stupor, a man’s body can cope without additional intake of the drug. For men after 35 years, a therapeutic course of treatment with this drug is prescribed, which in a short time helps to fully restore erectile function. Men of old age and advanced age will also feel a significant result from taking the drug.

The remedy will help to increase physical endurance, continue sexual intercourse, which in general will significantly increase the diversity of sexual life. Intimate relationships occupy an important place in the life of men and women of all ages. Regular sexual activity in young and adult age reduces the risk of nervous disorders and prevents the occurrence of internal diseases of a person. In old age, intimate intimacy replenishes physical strength and gives a good sense of well-being.

Male sexual disorders can be associated with many factors: congenital dysfunction, psychological trauma, transferred viral and venereal diseases, age problems, heavy physical labor, the use of hormonal substances, heart disease, disorders in the endocrine system, urological diseases. In case of erectile dysfunction, you should contact specialists and consult a doctor before taking the drug.

Benefits of Cenforce® 200mg:

• double dosage of the active ingredient in 1 tablet Cenforce® 200mg;
• Cenforce® 200mg effectively eliminates impotence and its symptoms;
• fights against age-related diseases;
• helps men even with the most serious diseases of the reproductive system.
• Buying Cenforce® 200mg means saving money, because one tablet is enough for two uses (subject to taking half a day).

Application Cenforce® 200mg

Cenforce® 200mg are oral tablets. The product is washed down with a small amount of clean water. The required dose is calculated based on the individual characteristics of the body. For a healthy man weighing up to 100 kg, a dose of 50 mg is recommended.If there is no effect, the dose is increased to 100 mg, but this is the maximum daily dose. The effect of admission manifests itself in an hour and has a duration of two to four hours. The drug is excreted naturally within a day. It is not recommended to combine the use of the agent with alcoholic beverages and nicotine. Fatty foods and juices of citrus fruits significantly reduce the effect of the drug.

Overdose Cenforce® 200mg

• Symptoms: With a single dose of Sildenafil in doses up to 800 mg, adverse reactions are similar to those when taking the drug in lower doses, with increased severity and frequency. Reception of Sildenafil dose 200 mg did not lead to an increase in effectiveness, but the frequency of adverse reactions (headache, feeling of “hot flashes”, dizziness, dyspepsia, nasal congestion, visual disturbances) increased.
• Treatment: symptomatic. Hemodialysis is ineffective because sildenafil binds tightly to plasma proteins and is not excreted by the kidneys.

Special instructions before taking Cenforce ® 200mg

• Before applying drug therapy, it is necessary to evaluate the history and conduct a clinical examination to diagnose erectile dysfunction and identify its possible causes.
• Drugs for the treatment of sexual dysfunction, including sildenafil, should be used with caution in patients with anatomical deformities of the penis (cavernous fibrosis or Peyronie’s disease), as well as in patients with conditions conducive to priapism (eg, sickle cell anemia, multiple myeloma or leukemia).
• Drugs for the treatment of erectile dysfunction, including Sildenafil, should not be used in men who are not recommended for sexual activity. Sexual activity is a certain risk in diseases of the cardiovascular system. Therefore, before starting any therapy for erectile dysfunction, it is necessary to evaluate the patient’s condition.

Buy Cenforce® 200 mg

You can buy Cenforce® 200 mg  in our online store usmeds.us at a reasonable price. With us you can count on constant promotions, discounts and bonuses, the possibility of delivery to any city in Germany.

Cenforce® 200 mg sold by us are incredibly popular among those who prefer high quality and long lasting sex. It is very rare for side effects to occur until users have reported their occurrence. In addition, we establish a reasonable value for our products. If you constantly use Cenforce® 200 mg, you can notice an improvement in potency and libido.

Cenforce® (Sildenafil Citrate) – dosages available

• Cenforce® 25 mg
• Cenforce® 50 mg
• Cenforce® 100 mg
• Cenforce® 120 mg
• Cenforce® 150 mg
• Cenforce® 200 mg

Order Cenforce® 200mg

Cenforce® 200mg is virtually identical to Viagra and contains the same active ingredients. Some even say that Cenforce® 200mg works even better than Viagra. The side effects of Cenforce® 200mg are not that bad – only one in 70 men experiences minor side effects. That is why Cenforce® 200mg is so popular among men who have erectile dysfunction or just want to have fun. On the website usmeds.us you are in the right place to order Cenforce® 200mg quickly and safely. We are the official distributor of Centurion Laboratories and you only buy original products from us.

Precautions when taking Cenforce® 200 mg tablets

As for contraindications to the drug, almost all of them are standard. So, it is forbidden to use the drug for female persons and adolescents under 18 years of age. Refrain from using it should and people suffering from atherosclerosis, open ulcers, multiple melanoma, injuries of the spine, stroke, tendency to priapism, deformation of the penis. If allergic reactions occur after taking the drug, you must urgently contact the attending therapist.

Together with other effective tablets for restoring potency, Cenforce® 200mg can affect the occurrence of side effects. Modern drugs are almost one hundred percent safe. But sometimes during the action people face chest pain, dizziness, nasal congestion, a state of weakness, drowsiness.

Contraindications to the use of Cenforce ® 200 mg

• Hypersensitivity to sildenafil or any other component of the drug;
• concomitant use with nitric oxide (NO) donors (for example, amyl nitrite) or nitrates in any form, because sildenafil may potentiate the antihypertensive effect of nitrates (mediated by NO/cGMP);
• drugs for the treatment of erectile dysfunction, including Sildenafil, should not be used in men who do not recommend sexual activity (for example, patients with severe cardiovascular diseases, such as: unstable angina pectoris or severe heart failure);
• the safety and efficacy of sildenafil in combination with other drugs for the treatment of erectile dysfunction have not been studied; therefore, concomitant use is contraindicated;
• Concomitant use with ritonavir is contraindicated;
• loss of vision in one eye due to anterior ischemic optic neuropathy of non-arterial origin, regardless of whether it is associated with the use of PDE5 inhibitors or not;
• the use is contraindicated in: severe violations of the liver, arterial hypotension (blood pressure less than 90/50 mm Hg. (hereditary degenerative diseases of the retina), such as retinitis pigmentosa (some patients have genetic defects retinal phosphodiesterase), because.Safety of using the drug Cenforce® 200 mdu such patients has not been studied.

Cenforce® 200mg taken with caution

• arterial hypertension (blood pressure over 170/100 mm Hg); life-threatening arrhythmias; obstruction of the tract of the left ventricle of the heart (aortic stenosis, hypertrophic obstructive cardiomyopathy (GOCMP));
• multiple systemic atrophy syndrome;
• anatomical deformation of the penis (angulation, cavernous fibrosis or Peyronie’s disease);
• Conditions predisposing to priapism (sickle cell anemia, multiple myeloma or leukemia);
• simultaneous intake of alpha-adrenoblockers;
• diseases accompanied by bleeding;
• Exacerbation of gastric ulcer or duodenum;
• episodes of development of anterior nearteritic ischemic neuropathy of the optic nerve in history.

Side effects of Cenforce® 200 mg

• From the immune system: rarely hypersensitivity reactions.
• From the nervous system: very often-headache; often-dizziness; rarely – drowsiness, hypoesthesia; rarely – violation of cerebral circulation, fainting; frequency unknown – transient ischemic attack, convulsions, relapse of convulsions.
• From the side of the organ of vision: often-visual impairment, violation of color perception (chromatopsia); rarely – the defeat of the conjunctiva, injury of the tear, other injuries of the organ of vision; frequency unknown – anterior ischemic optic neuropathy of non-arterial genesis, occlusion of the vessels of the retina, defective visual field.
• On the part of the auditory organ and labyrinthine disorders: often – vertigo, tinnitus; rarely – deafness (sudden decrease or loss of hearing was observed in a small number of cases when postmarketingovogo use or clinical trials with the use of any PDE5 inhibitors, including sildenafil) .
• From the vessels: often-a feeling of “tides”; rarely – increase/decrease in blood pressure.
• From the heart: rarely-heartbeat, tachycardia; rarely-myocardial infarction, atrial fibrillation; frequency unknown-ventricular arrhythmia, unstable angina pectoris, sudden cardiac death.
• Respiratory tract: often-stuffy nose; rarely: nosebleeds.
• From the digestive tract: often – dyspepsia; rarely – vomiting, nausea, dry mucous membrane of the oral cavity.
• From the skin and subcutaneous tissue: rarely-rash; frequency is unknown-Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome).
• Musculoskeletal system: rarely myalgia.
• From the urinary system: rarely-hematuria.
• From the genitals and breast: rarely – hematospermia, bleeding from the penis; the frequency is unknown – priapism, prolonged (prolonged) erection.
• Common reactions: rare – chest pain, increased fatigue.
• Laboratory and instrumental data: rarely-increase in heart rate.

Cenforce® 200mg – storage conditions

Shelf life 3 years. Store in the original packaging at a temperature not exceeding 30° C. Keep out of reach of children.